Ions, Cell Proliferation, and Cancer
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Ions, Cell Proliferation, and Cancer

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Published by Academic Pr .
Written in English


Book details:

The Physical Object
Number of Pages564
ID Numbers
Open LibraryOL7325856M
ISBN 100121230503
ISBN 109780121230500

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Ions, Cell Proliferation, and Cancer [Paperback] [] (Author) Alton L. Boynton on *FREE* shipping on qualifying offers. Ions, Cell Proliferation, and Cancer . ISBN: OCLC Number: Notes: "Proceedings of the Symposium on Ions, Cell Proliferation, and Cancer, sponsored by the National Cancer Institutes, the W. Alton Jones Cell Science Center, and the National Research Council of Canada, held at the W. Alton Jones Cell Science Center, Lake Placid, New York, July , "--Page [ii].   However, cancer cells evade cell death, tipping the balance to an overabundance of cell number. Therefore, overcoming this resistance to cell death is a decisive factor in the treatment of cancer. Ion channels play a critical role in cancer in regards to cell proliferation, malignant angiogenesis, migration and by: Cell proliferation in normal cells is a complex, well synchronized event that is stringently regulated by a number of ions, molecules and proteins associated with the cell cycle machinery including Ca ++, ATP, cyclins, cyclin dependent kinases and many other cell cycle regulators [11,12].A cell cycle can be distinguished into phases (), namely, the G0 phase, comprised mainly of the non.

After the early wavering steps tracing back to at least the ’s (Cone, ; Binggeli and Cameron, ), the study of ion transport in cell proliferation and neoplasia is on its way to become a mature research field (Arcangeli at al., ). Wide evidence is now available about the regulatory roles exerted by ion channels and transporters on the cell cycle phases (Becchetti, ) and. However, cancer cells evade cell death, tipping the balance to an overabundance of cell number. Therefore, overcoming this resistance to cell death is a decisive factor in the treatment of cancer. Ion channels play a critical role in cancer in regards to cell proliferation, malignant angiogenesis, migration and .   Hoffmann, E. K. Ion channels involved in cell volume regulation: effects on migration, proliferation, and programmed cell death in non adherent EAT cells and adherent ELA cells. Cell .   Killing cancer cells by cytotoxic T lymphocytes (CTL) and by natural killer (NK) cells is of vital importance. Cancer cell proliferation and apoptosis depend on the intracellular Ca 2 + concentration, and the expression of numerous ion channels with the ability to control intracellular Ca 2 + concentrations has been correlated with cancer. A rise of intracellular Ca 2 + concentrations is also.

  Functional assays in vitro. To assess the effects of treatment on proliferation, cells were seeded after treatment into 96 transparent well plates at a density of 5 × 10 3 cells per well. The. Changes of the electrical charges across the surface cell membrane are absolutely necessary to maintain cellular homeostasis in physiological as well as in pathological conditions. The opening of ion channels alter the charge distribution across the surface membrane as they allow the diffusion of ions such as K+, Ca++, Cl−, Na+. Traditionally, voltage-gated ion channels (VGIC) are known to. signalling in promoting tumour cell proliferation and migration. 12 Intriguingly, copper‐specific chelators or inhibitors of ATOX1 and CCS have been demonstrated to be capable of suppressing the proliferation of several cancer cells. 9,12,13 Tetrathiomolybdate (TM), a well‐tolerated copper chelator, is shown to inhibit tumour angiogen ‐. Rozengurt E () Monovalent ion fluxes, cyclic nucleotides and the stimulation of DNA synthesis in quiescent cells. In: Boynton AL, McKeehan WL, Whitfield JF (eds) Ions, cell proliferation and cancer. Academic Press, London, New York, pp – Google Scholar.